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Biocompatible Polyhydroxyethylaspartamide-based Micelles with Gadolinium for MRI Contrast Agents
- Authors
- Jeong, Sang Young; Kim, Hyo Jeong; Kwak, Byung-Kook; Lee, Ha-Young; Seong, Hasoo; Shin, Byung Cheol; Yuk, Soon Hong; Hwang, Sung-Joo; Cho, Sun Hang
- Issue Date
- Dec-2010
- Publisher
- SPRINGER
- Keywords
- MRI contrast agent; PHEA derivatives; Micelles; Nanoparticles; Gd contrast agent
- Citation
- NANOSCALE RESEARCH LETTERS, v.5, no.12, pp 1970 - 1976
- Pages
- 7
- Journal Title
- NANOSCALE RESEARCH LETTERS
- Volume
- 5
- Number
- 12
- Start Page
- 1970
- End Page
- 1976
- ISSN
- 1556-276X
1556-276X
- Abstract
- Biocompatible poly-[N-(2-hydroxyethyl)-D, L-aspartamide]- methoxypoly(ethyleneglycol)-hexadecylamine (PHEA-mPEG-C-16) conjugated with 1,4,7,10-tetraazacyclododecan- 1,4,7,10-tetraacetic acid-gadolinium (DOTA-Gd) via ethylenediamine (ED) was synthesized as a magnetic resonance imaging (MRI) contrast agent. Amphiphilic PHEA-mPEG-C-16-ED-DOTA-Gd forms micelle in aqueous solution. All the synthesized materials were characterized by proton nuclear magnetic resonance (H-1 NMR). Micelle size and shape were examined by dynamic light scattering (DLS) and atomic force microscopy (AFM). Micelles with PHEA-mPEG-C-16-ED-DOTA-Gd showed higher relaxivities than the commercially available gadolinium contrast agent. Moreover, the signal intensity of a rabbit liver was effectively increased after intravenous injection of PHEA-mPEG-C-16-ED-DOTA-Gd.
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