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Simultaneous GC-MS Analysis of Melatonin and Its Precursors as Ethoxycarbonyl/Pentafluoropropionyl Derivatives in Rat Urine
- Authors
- Paik, M. J.; Nguyen, D. T.; Kim, Y. J.; Shin, J. Y.; Shim, W.; Cho, E. Y.; Yoon, J. H.; Kim, K. R.; Lee, Y. S.; Kim, N.; Park, S. W.; Lee, G.; Ahn, Y. H.
- Issue Date
- Dec-2010
- Publisher
- SPRINGER HEIDELBERG
- Keywords
- Gas chromatography-mass spectrometry; Ethoxycarbonyl/pentafluoropropionyl derivatives; Melatonin, acetylserotonin and serotonin
- Citation
- CHROMATOGRAPHIA, v.72, no.11-12, pp 1213 - 1217
- Pages
- 5
- Journal Title
- CHROMATOGRAPHIA
- Volume
- 72
- Number
- 11-12
- Start Page
- 1213
- End Page
- 1217
- ISSN
- 0009-5893
1612-1112
- Abstract
- Melatonin is synthesized from acetylserotonin, which is a deacetylated product of serotoinin. Simultaneous analysis of melatonin and its precursors in rat urine was performed using their (N,O)-ethoxycarbonyl/N-pentafluoropropionyl (EOC/PFP) derivatives by gas chromatography-mass spectrometry (GC-MS). The mass spectral data of acetylserotonin as mono-O-EOC/mono-N-PFP and serotonin as di-(N,O)-EOC/di-N-PFP derivatives were newly established. This method exhibited good linearity (r >= 0.996), repeatability (% relative standard deviation = 6.9-9.4), accuracy (% relative error = -8.9 to 8.6) with detection limits of 0.005 to 0.03 ng mL(-1). This method was developed for the simultaneous measurement of melatonin and its precursors in rat urine.
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