Inhibitory Effects of Phenolic Compounds from Needles of Pinus densiflora on Nitric Oxide and PGE(2) Production
- Authors
- Kwon, Joo Hee; Kim, Jee Hun; Choi, Sun Eun; Park, Kwan Hee; Lee, Min Won
- Issue Date
- Dec-2010
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Pinus densiflora; Anti-inflammatory activity; Nitric oxide synthase; Cyclooxygenase; Nitric oxide; Prostaglandin E-2
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.33, no.12, pp 2011 - 2016
- Pages
- 6
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 33
- Number
- 12
- Start Page
- 2011
- End Page
- 2016
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22057
- DOI
- 10.1007/s12272-010-1217-y
- ISSN
- 0253-6269
- Abstract
- The needles of Pinus densiflora Siebold et Zuccarini, a representative Pinus species that grows in Korea, have been used in oriental traditional medicine as remedies for rheumatitis, hemorrhage, cancer, etc. Phytochemical examination of the needles of Pinus densiflora Siebold et Zuccarini led to the isolation of four lignans, one flavan-3-ol, two flavonols and one organic acid. They were identified as icariside E-4 (1), cupressoside A (2), schizandriside (3), (+)-isolariciresinol (4), (+)-catechin (5), quercetin 3-O-beta-D-glucopyranoside (6), 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-beta-D-glucopyranoside (7) and (-)-shikimic acid (8). In order to evaluate the anti-inflammatory effects of these compounds, their inhibitory activities against nitric oxide and prostaglandin E-2 production in IFN-gamma- and lipopolysaccharide-stimulated RAW 264.7 cells were examined.
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