Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus
- Authors
- Kim, Ju Hwan; Sohn, Uy Dong; Kim, Hyung-Gun; Kim, Hak Rim
- Issue Date
- May-2018
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Apoptosis; Autophagy; Calcium channels; Hippocampus; Radiofrequency electromagnetic field
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.22, no.3, pp 277 - 289
- Pages
- 13
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 22
- Number
- 3
- Start Page
- 277
- End Page
- 289
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2206
- DOI
- 10.4196/kjpp.2018.22.3.277
- ISSN
- 1226-4512
2093-3827
- Abstract
- The exponential increase in the use of mobile communication has triggered public concerns about the potential adverse effects of radiofrequency electromagnetic fields (RF-EMF) emitted by mobile phones on the central nervous system (CNS). In this study, we explored the relationship between calcium channels and apoptosis or autophagy in the hippocampus of C57BL/6 mice after RF-EMF exposure with a specific absorption rate (SAR) of 4.0 W/kg for 4 weeks. Firstly, the expression level of voltage-gated calcium channels (VGCCs), a key regulator of the entry of calcium ions into the cell, was confirmed by immunoblots. We investigated and confirmed that pan-calcium channel expression in hippocampal neurons were significantly decreased after exposure to RF-EMF. With the observed accumulation of autolysosomes in hippocampal neurons via TEM, the expressions of autophagyrelated genes and proteins (e.g., LC3B-II) had significantly increased. However, down-regulation of the apoptotic pathway may contribute to the decrease in calcium channel expression, and thus lower levels of calcium in hippocampal neurons. These results suggested that exposure of RF-EMF could alter intracellular calcium homeostasis by decreasing calcium channel expression in the hippocampus; presumably by activating the autophagy pathway, while inhibiting apoptotic regulation as an adaptation process for 835 MHz RF-EMF exposure.
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