Visible light-induced crosslinkable gelatin
- Authors
- Son, Tae Il; Sakuragi, Makoto; Takahashi, Sawa; Obuse, Sei; Kang, Jeonghwa; Fujishiro, Masako; Matsushita, Haruhiko; Gong, Jiansheng; Shimizu, Shigeru; Tajima, Yusuke; Yoshida, Yasuhiro; Suzuki, Kazuomi; Yamamoto, Toshio; Nakamura, Mariko; Ito, Yoshihiro
- Issue Date
- Oct-2010
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Gelatin; Photo-crosslinking; Biosealant; Direct pulp capping; Visible light
- Citation
- ACTA BIOMATERIALIA, v.6, no.10, pp 4005 - 4010
- Pages
- 6
- Journal Title
- ACTA BIOMATERIALIA
- Volume
- 6
- Number
- 10
- Start Page
- 4005
- End Page
- 4010
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22188
- DOI
- 10.1016/j.actbio.2010.05.018
- ISSN
- 1742-7061
1878-7568
- Abstract
- A novel visible light-crosslinkable porcine gelatin was prepared for gelation and micropatterning The preparation employed a photo-oxidation-induced crosslinking mechanism. First, furfuryl groups were incorporated into the gelatin Second, the modified gelatin was mixed in water with Rose Bengal, which is a visible light sensitizer. Irradiation by visible light solidified the aqueous solution. In addition, when the solution was cast on a plate, dried and photo-irradiated in the presence of a photomask a micropattern was formed that matched the micropattern on the photomask The gelatin-immobilized regions enhanced cell adhesion. It was also confirmed that the gelatin incorporating furfuryl and Rose Bengal have no significant toxicity. The photo-crosslinkable gelatin was employed as a direct pulp capping material in the dental field. Considering these results, this system could be useful as a new type of visible light-induced crosslinkable biosealant. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All lights reserved.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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