Liquid-Phase Synthesis of Biaryl Compounds by the Hydrogenolysis of Pentaerythritol-Supported Biarylsulfonates
- Authors
- Kim, Chul-Bae; Lee, Sung-Kyung; Park, Kwangyong
- Issue Date
- Sep-2010
- Publisher
- 대한화학회
- Keywords
- Soluble support; Liquid-phase synthesis; Traceless; Parallel synthesis; Combinatorial synthesis; Biaryls
- Citation
- Bulletin of the Korean Chemical Society, v.31, no.9, pp 2459 - 2466
- Pages
- 8
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 31
- Number
- 9
- Start Page
- 2459
- End Page
- 2466
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22197
- DOI
- 10.5012/bkcs.2010.31.9.2459
- ISSN
- 0253-2964
1229-5949
- Abstract
- Unfunctionalized biaryl compounds were parallelly and combinatorially prepared by the traceless hydrogenolysis of biarylsulfonates supported on pentaerythritol. The hydrogenolysis using 2-propylmagnesium chloride in the presence of dppfNiCl(2) efficiently generated corresponding biaryl derivatives without any memory of the support. The strategy using pentaerythritol as a small soluble support was disclosed to have a potential to combine the benefits of both SPOS and solution-phase reaction with fast reaction rate, facile isolation of intermediates, easy analysis of intermediates and atom economical manner. The novel tetrapodal support is expected to be an efficient substitute for polymeric supports in many circumstances.
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- Appears in
Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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