Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells
- Authors
- Lee, A. Hyeong; Oh, Kyung Taek; Baik, Hye Jung; Lee, Bo Reum; Oh, Young Taik; Lee, Don Haeng; Lee, Eun Seong
- Issue Date
- 20-Aug-2010
- Publisher
- KOREAN CHEMICAL SOC
- Keywords
- Worm-like micelle; Multiple ligands; Tumor targeting
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.31, no.8, pp 2265 - 2271
- Pages
- 7
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 31
- Number
- 8
- Start Page
- 2265
- End Page
- 2271
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22259
- DOI
- 10.5012/bkcs.2010.31.8.2265
- ISSN
- 0253-2964
1229-5949
- Abstract
- In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self- assembly that consisted of a relatively long PLLA block (M-n 7K Daltons) at the core and a relatively short PEG block (M-n 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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