Apoptotic Effect of Quercetin on HT-29 Colon Cancer Cells via the AMPK Signaling Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyeong-Jin | - |
dc.contributor.author | Kim, Sang-Ki | - |
dc.contributor.author | Kim, Byeong-Soo | - |
dc.contributor.author | Lee, Seung-Ho | - |
dc.contributor.author | Park, Young-Seok | - |
dc.contributor.author | Park, Byung-Kwon | - |
dc.contributor.author | Kim, So-Jung | - |
dc.contributor.author | Kim, Jin | - |
dc.contributor.author | Choi, Changsun | - |
dc.contributor.author | Kim, Jong-Suk | - |
dc.contributor.author | Cho, Sung-Dae | - |
dc.contributor.author | Jung, Ji-Won | - |
dc.contributor.author | Roh, Kyong-Hwan | - |
dc.contributor.author | Kang, Kyung-Sun | - |
dc.contributor.author | Jung, Ji-Youn | - |
dc.date.available | 2019-05-30T00:55:50Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22265 | - |
dc.description.abstract | Activation of AMP-activated protein kinase (AMPK), a physiological cellular energy sensor, strongly suppresses cell proliferation in both nonmalignant and tumor cells. This study demonstrates the mechanism of quercetin-induced apoptosis in HT-29 colon cancer cells. Treatment of cells with quercetin significantly decreased cell viability in a dose-dependent manner. Notably, quercetin increased cell cycle arrest in the G1 phase and up-regulated apoptosis-related proteins, such as AMPK, p53, and p21, within 48 h. Furthermore, in vivo experiments showed that quercetin treatment resulted in a significant reduction in tumor volume over 6 weeks, and apoptosis-related protein induction by quercetin was significantly higher in the 100 mg/kg treated group compared to the control group. All of these results indicate that quercetin induces apoptosis via AMPK activation and p53-dependent apoptotic cell death in HT-29 colon cancer cells and that it may be a potential chemopreventive or therapeutic agent against HT-29 colon cancer. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Apoptotic Effect of Quercetin on HT-29 Colon Cancer Cells via the AMPK Signaling Pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/jf101510z | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.58, no.15, pp 8643 - 8650 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000280471800025 | - |
dc.identifier.scopusid | 2-s2.0-77955699748 | - |
dc.citation.endPage | 8650 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 8643 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 58 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Quercetin | - |
dc.subject.keywordAuthor | HT-29 | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | p53 | - |
dc.subject.keywordAuthor | p21 | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | CYCLE PROGRESSION | - |
dc.subject.keywordPlus | CLEAVED CASPASE-3 | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | IMMUNOHISTOCHEMISTRY | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | LINE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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