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Species Distribution and Antifungal Susceptibilities of Yeast Clinical Isolates from Three Hospitals in Korea, 2001 to 2007

Authors
Lee, Mi-KyungYong, DongeunKim, MyungsookKim, Mi-NaLee, Kyungwon
Issue Date
Aug-2010
Publisher
KOREAN SOC LABORATORY MEDICINE
Keywords
Yeast; Fluconazole; Voriconazole; Surveillance
Citation
KOREAN JOURNAL OF LABORATORY MEDICINE, v.30, no.4, pp 364 - 372
Pages
9
Journal Title
KOREAN JOURNAL OF LABORATORY MEDICINE
Volume
30
Number
4
Start Page
364
End Page
372
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22280
DOI
10.3343/kjlm.2010.30.4.364
ISSN
1598-6535
2234-3814
Abstract
Background : We utilized results from the ARTEMIS DISK Global Antifungal Surveillance Program to evaluate the species distribution and fluconazole and voriconazole susceptibilities of yeast isolates from clinical specimens in South Korea from 2001 to 2007. Methods : Data were collected on 5,665 yeast isolates from all body sites at three locations. All investigators tested clinical yeast isolates using the CLSI M44-A disk diffusion method. Test plates were automatically read and results were recorded using the BIOMIC image analysis plate reader system (Giles Scientific, USA). Species, drug, zone diameter, susceptibility category, and quality control results were collected quarterly via e-mail for analysis. Results: Candida albicans was the most common isolate, but a progressive increase in non-C. albicans Candida and noncandidal yeast species has been observed in recent years. The overall percentages of isolates in each category (susceptible, susceptible dose dependent, and resistant) were 98.8%, 0.5%. and 0.7% and 99.2%, 0.2%, and 0.6% for fluconazole and voriconazole, respectively. Candida of 3 species exhibited decreased susceptibility to fluconazole (<90% S) in the order of that seen with the resistant (R) species: C. krusei, C. guilliermondii, and C. glabrata. Emerging resistance to fluconazole or voriconazole was documented among isolates of Cryptococcus neoformans, Trichosporon spp., and Rhodotorula spp. Conclusions : The species distribution and antifungal susceptibilities of yeasts may differ according to specimen type, testing method, hospital, and geographic region. Therefore, further large-scaled, long-term surveillance studies are needed to isolate yeasts and to confirm the species distribution and antifungal susceptibilities of yeast isolates from clinical specimens in Korea. (Korean J Lab Med 2010;30:364-72)
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의과대학 (의학부(임상-서울))
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