Isolation and Anti-Inflammatory Activity of Bakuchiol from Ulmus davidiana var. japonica
- Authors
- Choi, Sang Yoon; Lee, Sanghyun; Choi, Won-Hee; Lee, Yeonmi; Jo, Youn Ock; Ha, Tae-Youl
- Issue Date
- Aug-2010
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- bakuchiol; nitric oxide; Ulmus davidiana var; japonica
- Citation
- JOURNAL OF MEDICINAL FOOD, v.13, no.4, pp 1019 - 1023
- Pages
- 5
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 13
- Number
- 4
- Start Page
- 1019
- End Page
- 1023
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22287
- DOI
- 10.1089/jmf.2009.1207
- ISSN
- 1096-620X
1557-7600
- Abstract
- The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly exhibits antioxidant, anticancer, and anti-inflammatory effects. A search for biologically active compounds in U. davidiana var. japonica extracts yielded bakuchiol, which we structurally identified on the basis of spectral data, including two-dimensional nuclear magnetic resonance spectroscopy and distortionless enhancement by polarization transfer. In our study, bakuchiol ( 50 mu M) inhibited lipopolysaccharide-induced nitric oxide and prostaglandin E-2 production in RAW 264.7 macrophages by 53.7% and 84.2%, respectively. These results suggested that bakuchiol is one of the potent anti-inflammatory components of U. davidiana var. japonica.
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Collections - College of Biotechnology & Natural Resource > ETC > 1. Journal Articles
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