Detailed Information
Cited 66 time in 
Cited 82 time in 
Cited 82 time in
Metadata Downloads
A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: In vitro evaluation
- Authors
- Oh, Nam Muk; Oh, Kyung Taek; Baik, Hye Jung; Lee, Bo Reum; Lee, A. Hyeong; Youn, Yu Seok; Lee, Eun Seong
- Issue Date
- Jun-2010
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- pH-responsive nanogel; Glycol chitosan; 3-Diethylaminopropyl; Tumor extracellular pH
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.78, no.1, pp 120 - 126
- Pages
- 7
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 78
- Number
- 1
- Start Page
- 120
- End Page
- 126
- ISSN
- 0927-7765
1873-4367
- Abstract
- In this study, a novel pH-responsive nanogel composed of glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups (denoted as GCS-g-DEAP hereafter) was fabricated. The GCS-g-DEAP was designed to have a self-assembled arrangement consisting of hydrophilic block (GCS) and hydrophobic block (DEAP) at physiological pH. As the pH decreased to tumor extracellular pH (pH(e)), the nanogel was destabilized due to the protonation of DEAP. The pH-responsive property of the nanogel at tumor extracellular pH (pH(e)) was characterized in drug-release kinetic studies. The release of doxorubicin (DOX) from DOX-loaded nanogels was significantly accelerated at lower pH values, which allowed for increased DOX uptake by non-small lung carcinoma A546 cells under a slightly acidic pH condition, as in tumor pH(e). (C) 2010 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.