Casein kinase 2 inhibition differentially modulates apoptotic effect of trichostatin A against epithelial ovarian carcinoma cell lines
- Authors
- Lee, Chung Soo; Jang, Eun-Ra; Kim, Yun Jeong; Myung, Soon Chul; Kim, Wonyong
- Issue Date
- May-2010
- Publisher
- SPRINGER
- Keywords
- Histone deacetylase inhibitors; Casein kinase 2 inhibitors; Epithelial ovarian adenocarcinoma cell lines; Apoptotic proteins
- Citation
- MOLECULAR AND CELLULAR BIOCHEMISTRY, v.338, no.1-2, pp 157 - 166
- Pages
- 10
- Journal Title
- MOLECULAR AND CELLULAR BIOCHEMISTRY
- Volume
- 338
- Number
- 1-2
- Start Page
- 157
- End Page
- 166
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22471
- DOI
- 10.1007/s11010-009-0349-1
- ISSN
- 0300-8177
1573-4919
- Abstract
- Histone deacetylase inhibitors and casein kinase 2 inhibitors have been shown to induce apoptosis. However, the combined effect of casein kinase 2 inhibition on the apoptotic effect of histone deacetylase inhibitor is unknown. We assessed the effect of casein kinase 2 inhibition on the apoptotic effect of trichostatin A in human epithelial carcinoma cell lines with respect to cell death signaling pathways. At concentrations that did not induce cell death, the casein kinase 2 inhibitor 4,5,6,7-tetrabromobenzotriazole inhibited activation of apoptotic proteins and changes in mitochondrial membrane permeability induced by the histone deacetylase inhibitor trichostatin A. These results suggest that casein kinase 2 inhibition may reduce trichostatin A-induced apoptosis in ovarian carcinoma cell lines by suppressing activation of apoptotic proteins and changes in mitochondrial membrane permeability, which both lead to caspase-3 activation. Casein kinase 2 inhibition, which does not induce a cytotoxic effect, may prevent histone deacetylase inhibitor-mediated apoptosis.
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