Intraperitoneal Ropivacaine for Effective Pain Relief after Laparoscopic Appendectomy: a Prospective, Randomized, Double-blind, placebo-controlled Study
- Authors
- Kang, H.; Kim, B-G
- Issue Date
- May-2010
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- ROPIVACAINE; ANAESTHESIA; PRE-EMPTIVE ANALGESIA; POST-OPERATIVE PAIN; APPENDECTOMY; LAPAROSCOPIC SURGERY; INTRAPERITONEAL INSTILLATION
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.38, no.3, pp 821 - 832
- Pages
- 12
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 38
- Number
- 3
- Start Page
- 821
- End Page
- 832
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22477
- DOI
- 10.1177/147323001003800309
- ISSN
- 0300-0605
1473-2300
- Abstract
- This prospective, randomized, double-blind, placebo-controlled study evaluated the effectiveness of intraperitoneal instillation of ropivacaine in the relief of pain in patients undergoing laparoscopic appendectomy. Patients in group C (placebo control group; n = 33) received normal saline and those in group I (instillation group; n = 30) received an instillation of 2 mg/kg ropivacaine at the initiation of the pneumoperitoneum. Visual analogue scale pain scores, fentanyl consumption and the frequency at which patients pushed the button (FPB) of a patient-controlled analgesia system during the post-operative period were significantly lower in group I compared with group C, and decreased gradually with time in both groups. The total amount of fentanyl consumed and the total FPB were significantly lower in group I compared with group C. Thus, intraperitoneal ropivacaine instillation reduced pain during the post-operative period after laparoscopic appendectomy. In addition, this drug was easy to administer and had no adverse effects at the dose used.
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