Synthesis and biological evaluation of water-soluble organogermanium
DC Field | Value | Language |
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dc.contributor.author | Choi, Sumi | - |
dc.contributor.author | Oh, Changwon | - |
dc.contributor.author | Han, Jeongsoo | - |
dc.contributor.author | Park, Jina | - |
dc.contributor.author | Choi, Jee-Hye | - |
dc.contributor.author | Min, Na Young | - |
dc.contributor.author | Lee, Kwang-Ho | - |
dc.contributor.author | Park, Ae Ja | - |
dc.contributor.author | Kim, Yeo Jin | - |
dc.contributor.author | Jang, Su Jeong | - |
dc.contributor.author | Lee, Duck-Hyung | - |
dc.contributor.author | Ham, Seung Wook | - |
dc.date.available | 2019-05-30T01:39:23Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.issn | 1768-3254 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22546 | - |
dc.description.abstract | Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study. Crown Copyright (c) 2010 Published by Elsevier Masson SAS. All rights reserved. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.title | Synthesis and biological evaluation of water-soluble organogermanium | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ejmech.2009.12.069 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, no.4, pp 1654 - 1656 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000276054900049 | - |
dc.identifier.scopusid | 2-s2.0-77349083428 | - |
dc.citation.endPage | 1656 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1654 | - |
dc.citation.title | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.type.docType | Article | - |
dc.publisher.location | 프랑스 | - |
dc.subject.keywordAuthor | Organogermanium | - |
dc.subject.keywordAuthor | Interferon | - |
dc.subject.keywordAuthor | Immune modulator | - |
dc.subject.keywordPlus | GERMANIUM SESQUIOXIDE | - |
dc.subject.keywordPlus | PROPAGERMANIUM | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | GE-132 | - |
dc.subject.keywordPlus | FACTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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