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Synthesis and biological evaluation of water-soluble organogermanium
- Authors
- Choi, Sumi; Oh, Changwon; Han, Jeongsoo; Park, Jina; Choi, Jee-Hye; Min, Na Young; Lee, Kwang-Ho; Park, Ae Ja; Kim, Yeo Jin; Jang, Su Jeong; Lee, Duck-Hyung; Ham, Seung Wook
- Issue Date
- Apr-2010
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Keywords
- Organogermanium; Interferon; Immune modulator
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.45, no.4, pp 1654 - 1656
- Pages
- 3
- Journal Title
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Volume
- 45
- Number
- 4
- Start Page
- 1654
- End Page
- 1656
- ISSN
- 0223-5234
1768-3254
- Abstract
- Interferon (INF) is an effective drug in treating several human diseases. Ge-132, which is the most common and well-studied organic germanium, has been reported to induce INF-gamma and has undergone clinical trials with promising preclinical results. However, it has been reported that long-term ingestion or high doses of organic Ge-132 causes similar toxic effects as GeO(2) because Ge-132 can be easily contaminated with significant amounts of inorganic germanium during the preparation. In this study, we synthesized the water-soluble organogermanium compound (Ge-OH) without possible contamination with toxic inorganic germanium and showed that Ge-OH is a better INF-gamma inducer than Ge-132 by an animal study. Crown Copyright (c) 2010 Published by Elsevier Masson SAS. All rights reserved.
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