Quercetin-3-O-beta-D-glucuronopyranoside (QGC)-induced HO-1 expression through ERK and PI3K activation in cultured feline esophageal epithelial cells
- Authors
- Kim, Ji Soo; Song, Hyun Ju; Ko, Sung Kwon; Whang, Wan Kyunn; Sohn, Uy Dong
- Issue Date
- Mar-2010
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- ERK; Esophageal epithelial cells; HO-1; Nrf2; PI3K/Akt; QGC
- Citation
- FITOTERAPIA, v.81, no.2, pp 85 - 92
- Pages
- 8
- Journal Title
- FITOTERAPIA
- Volume
- 81
- Number
- 2
- Start Page
- 85
- End Page
- 92
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22600
- DOI
- 10.1016/j.fitote.2009.08.008
- ISSN
- 0367-326X
1873-6971
- Abstract
- Heme oxygenase-1 (HO-1) is one of the antioxidant enzymes which help protect against cellular damage. The present study examined the ability of Quercetin-3-O-beta-D-glucuronopyranoside (QGC), flavonoid glucoside extracted from Rumex Aquaticus Herba, to induce expression of HO-1 and analyzed its signaling mechanism in cultured feline esophageal epithelial cells (EEC). Culture of the esophageal epithelial cells from cat was prepared. The data suggested that QGC could result in enhanced antioxidant enzyme defense system via HO-1 expression and Nrf2 translocation involving both the ERK and PI3K-Akt pathways as well as partly PKC pathways in EEC. (C) 2009 Published by Elsevier B.V.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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