Clinical efficacy and tolerance of 1% nadifloxacin cream in the treatment of mild to moderate acne vulgaris in South KoreaClinical Efficacy and Tolerance of 1% Nadifloxacin Cream in the Treatment of Mild to Moderate Acne Vulgaris in South Korea
- Authors
- Choi, W.J.; Kim, K.J.; Kim, N.I.; Kye, Y.C.; Suh, D.H.; Lee, J.H.; Kim, M.N.; Lee, E.S.; Lee, J.H.; Ro, Y.S.
- Issue Date
- Aug-2010
- Publisher
- 대한피부과학회
- Keywords
- 1% nadifloxacin cream; Acne; Treatment
- Citation
- Korean Journal of Dermatology, v.48, no.8, pp 665 - 671
- Pages
- 7
- Journal Title
- Korean Journal of Dermatology
- Volume
- 48
- Number
- 8
- Start Page
- 665
- End Page
- 671
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22743
- ISSN
- 0494-4739
- Abstract
- Background: Antimicrobials have been a mainstay of inflammatory acne treatment for more than 30 years. However, antibiotic-resistant propionibacteria had been isolated with increased frequency, and associated with failure to respond to antibiotic therapy. Objective: The aim of this study was to investigate the clinical efficacy and tolerance of 1% nadifloxacin cream. Methods: In the final analysis, 197 patients with mild to moderate facial acne vulgaris were enrolled. The patients were instructed to apply 1% nadifloxacin cream twice daily to the affected skin after washing the face. Following 2 and 4 weeks of treatment, patients were observed for clinical response: number of the acne lesions, Korea acne grading system (KAGS), global improvement, and occurrence of adverse reactions. Results: During 4 weeks of treatment, nadifloxacin caused significant reduction in the number of inflamed papulo-pustular lesions and open/closed comedones. In addition, significant reduction of KAGS was observed. About 96% of patients showed clinical improvement in the overall evaluation of the therapeutic effect by physicians. All reported adverse events were mild. Conclusion: This study shows that 1% nadifloxacin cream can be an effective and safe treatment for mild to moderate acne vulgaris.
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