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Influence of Liposome Type and Skin Model on Skin Permeation and Accumulation Properties of Genistein

Authors
Kang, Kyoung HoonKang, Myung JooLee, JaehwiChoi, Young Wook
Issue Date
2010
Publisher
TAYLOR & FRANCIS INC
Keywords
Accumulation; elastic liposome; genistein; permeation; skin
Citation
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, v.31, no.8, pp 1061 - 1066
Pages
6
Journal Title
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Volume
31
Number
8
Start Page
1061
End Page
1066
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22802
DOI
10.1080/01932690903224813
ISSN
0193-2691
1532-2351
Abstract
This article investigates the impact of elastic liposomes on enhancing the skin delivery of genistein and the influences of skin tissues with or without hair follicles on permeation and accumulation properties of genistein from liposomal suspensions. The greater permeation rate and deposition values of genistein were observed from the elastic liposomes than conventional liposomes in haired skin. When measured with hairless skin, the flux and skin deposition values of genistein in elastic liposomes were significantly decreased compared to conventional liposomes, indicating that the percutaneous delivery of elastic liposomes was considerably influenced by existence of hair follicles in the skin tissue.
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