Hepatoprotective and Antioxidant Capacities of Paecilomyces japonica and Cordyceps sinensis in Rats with CCl4-Induced Hepatic Injury
- Authors
- Jung, Sang Hoon; Lee, Yeon Sil; Lim, Soon Sung; Kim, Yeong Shik; Lee, Sanghyun; Shin, Kuk Hyun
- Issue Date
- Dec-2009
- Publisher
- KOREAN SOC HORTICULTURAL SCIENCE
- Keywords
- antioxidant enzymes; DPPH; fungus; TBA-reactant assay; transaminase
- Citation
- KOREAN JOURNAL OF HORTICULTURAL SCIENCE & TECHNOLOGY, v.27, no.4, pp 668 - 672
- Pages
- 5
- Journal Title
- KOREAN JOURNAL OF HORTICULTURAL SCIENCE & TECHNOLOGY
- Volume
- 27
- Number
- 4
- Start Page
- 668
- End Page
- 672
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22864
- ISSN
- 1226-8763
2465-8588
- Abstract
- Antioxidant and hepatoprotective activities of the fruiting bodies of Paecilomyces japonica (PJ) grown on silk-worm larvae and of Cordyceps sinensis (CS), a wild form of Cordyceps, were investigated. The 70% ethanol extracts of both fungi, PJ and CS, were found to exhibit free radical scavenging effects on 1,1-diphenyl-2-picrylhydrazyl (DPPH). The inhibitory potency Of PJ (IC50 = 163 mu g.mL(-1)) was approximately 4.5 folds that of CS (IC50 = 731 mu g.mL(-1)). They exhibited a moderate decrease in serum transaminase activities elevated by hepatic damage induced by carbon tetrachloride (CCl4)-intoxication in rats. Both fungal extracts also exhibited not only significant increases in hepatic superoxide dismutase (SOD) and catalase at a dose of 300 mg.kg(-1) in CCl4-intoxicated rats, but also a significant decrease in malondialdehyde (MDA) production in a thiobarbituric acid (TBA) reactant assay in rats. Although no significant glutathione peroxidase (GSH-px) activity was detected, SOD and catalase elevations were obtained.
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