Detailed Information

Cited 12 time in webofscience Cited 0 time in scopus
Metadata Downloads

Acetoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase

Authors
Song, Ho SunSim, Sang Soo
Issue Date
Oct-2009
Publisher
WILEY
Keywords
acteoside; anti-oxidant; cAMP; melanin; tyrosinase
Citation
JOURNAL OF PHARMACY AND PHARMACOLOGY, v.61, no.10, pp 1347 - 1351
Pages
5
Journal Title
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume
61
Number
10
Start Page
1347
End Page
1351
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22978
DOI
10.1211/jpp/61.10.0011
ISSN
0022-3573
2042-7158
Abstract
Objectives The aim of the study was to determine the mechanism of the whitening effect of acteoside. Methods We used tyrosinase activity and melanin production stimulated in B16 melanoma cells by alpha-melanocyte stimulating hormone (alpha-MSH) or forskolin to measure the whitening effect of acteoside. Key findings Acteoside did not directly inhibit mushroom tyrosinase activity, but dose-dependently inhibited tyrosinase activity and melanin production in B16 melanoma cells stimulated by 1 mu mol/l alpha-MSH. Acteoside also reduced cyclic AMP levels in cells stimulated by 1 mu mol/l alpha-MSH, suggesting direct inhibition of adenyl cyclase. Acteoside also inhibited production of both melanin and cyclic AMP in cells stimulated by 1 mu mol/l forskolin,an adenyl cyclase activator. Acteoside showed antioxidant activity in a cell-free DPPH (1-diphenyl-2-picrylhydroazyl) assay and inhibited generation of intracellular reactive oxygen species. Conclusions These results suggest that the whitening activity of acteoside results from inhibition of adenyl cyclase and alpha-MSH signalling.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > School of Pharmacy > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE