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The Inhibitory Effect of Quercetin-3-O-beta-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats
- Authors
- Min, Young Sil; Lee, Se Eun; Hong, Seung Tae; Kim, Hyun Sik; Choi, Byung-Chul; Sim, Sang Soo; Whang, Wan Kyun; Sohn, Uy Dong
- Issue Date
- Aug-2009
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Reflux esophagitis; Lipid peroxidation; Gastritis; Quercetin-3-O-beta-D-glucuronopyranoside
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.13, no.4, pp 295 - 300
- Pages
- 6
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 13
- Number
- 4
- Start Page
- 295
- End Page
- 300
- ISSN
- 1226-4512
2093-3827
- Abstract
- It was evaluated the inhibitory action of quereetin-3-O-beta-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.
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