Increased expression of the testicular estrogen receptor alpha in adult mice exposed to low doses of methiocarb
- Authors
- Han, Jiyou; Park, Mira; Kim, Jae-Hong; Kim, Ahyoung; Won, Miae; Lee, Dong Ryul; Ko, Jeong-Jae; Yoon, Ho; Sim, Se-Hoon; Lee, Kangseok; Bae, Jeehyeon
- Issue Date
- Jul-2009
- Publisher
- John Wiley & Sons Inc.
- Keywords
- 3,5-dimethyl-1,4-methylthiophenyl-N-methylcarbamate; methiocarb; endocrine disrupter; estrogen receptor; male reproduction; spermatogenesis; testis; CASA
- Citation
- Journal of Applied Toxicology, v.29, no.5, pp 446 - 451
- Pages
- 6
- Journal Title
- Journal of Applied Toxicology
- Volume
- 29
- Number
- 5
- Start Page
- 446
- End Page
- 451
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23104
- DOI
- 10.1002/jat.1417
- ISSN
- 0260-437X
1099-1263
- Abstract
- Methiocarb is a widely used carbamate pesticide and a suspected endocrine disrupter. The objective of this study was to examine the in vivo effects of methiocarb at low doses on testicular expression of steroid receptors, spermatogenesis and sperm quality in adult mice. Eighteen-week-old DBA/2 males were treated with daily intraperitoneal injection of methiocarb (0, 0.03, 0.3, 1.0 or 3.0 mu g kg(-1) of body weight) for 20 days. Kidney and liver weights were significantly increased in the 1.0 or 3.0 mu g kg(-1) treatment groups (P < 0.05). The testicular expression of estrogen receptor alpha (ER alpha) was significantly increased in mice treated with methiocarb as confirmed by Western blot analysis. The sperm production and sperm quality of the methiocarb-exposed mice were not significantly altered as determined using a computer-assisted sperm analysis system. Therefore, these results demonstrate, that although the exposure to methiocarb at low doses alters testicular ERa expression in adult mice, both sperm production and quality remain unaffected. Copyright (C) 2009 John Wiley & Sons, Ltd.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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