The Clinical Significance in Healthy Men of the Association Between Obesity Related Plasma Hemodilution and Tumor Marker Concentration
- Authors
- Chang, In Ho; Ahn, Seung Hyun; Han, June Hyun; Kim, Tae-Hyoung; Kim, Young Sun; Myung, Soon Chul
- Issue Date
- Feb-2009
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- prostatic neoplasms; obesity; tumor markers; biological; hemodilution; body mass index
- Citation
- JOURNAL OF UROLOGY, v.181, no.2, pp 567 - 572
- Pages
- 6
- Journal Title
- JOURNAL OF UROLOGY
- Volume
- 181
- Number
- 2
- Start Page
- 567
- End Page
- 572
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23328
- DOI
- 10.1016/j.juro.2008.10.030
- ISSN
- 0022-5347
1527-3792
- Abstract
- Purpose: We investigated the association between body mass index and the concentration of tumor markers including carcinoembryonic antigen, alpha-fetoprotein, the carbohydrate antigen 19-9 and prostate specific antigen, as well as the association between body mass index changes and tumor marker concentration changes in a population of healthy men. Materials and Methods: We evaluated data on 8,776 men screened for tumor markers (carcinoembryonic antigen, a-fetoprotein, carbohydrate antigen 19-9 and prostate specific antigen) at least 3 times annually during an annual examination from 2001 to 2007. We assessed the tumor marker test findings for a trend in the age, alanine aminotransferase and creatinine adjusted tumor marker concentration by body mass index. We used multivariate regression analysis to determine whether a change in body mass index was associated with a tumor marker concentration change over time using calculated tumor markers, body mass index, creatinine and alanine aminotransferase concentration change per year. Results: After adjusting for age, creatinine and alanine aminotransferase a higher body mass index was associated with lower prostate specific antigen (p for trend <0.001), carcinoembryonic antigen (p for trend <0.001) and carbohydrate antigen 19-9 (p for trend <0.001). On multivariate regression analysis each I kg/m(2) of body mass index gain per year was associated with a -0.011 ng/ml change in prostate specific antigen concentration, a -0.030 ng/ml change in carcinoembryonic antigen concentration and a -0.192 IU/ml change in carbohydrate antigen 19-9 concentration per year. Conclusions: In this cohort of healthy men hemodilution from increased plasma volume may be responsible for the observed decreased tumor marker concentration in men with a higher body mass index. In addition, an increase in body mass index may predict a lower tumor marker concentration in an individual.
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