Biphasic increase of pro-inflammatory cytokines in mice lung after irradiation
DC Field | Value | Language |
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dc.contributor.author | Choi, Yun Jung | - |
dc.contributor.author | Rho, Jin Kyung | - |
dc.contributor.author | Jang, Won Seok | - |
dc.contributor.author | Lee, Seon Joo | - |
dc.contributor.author | Lee, Seung Sook | - |
dc.contributor.author | Koh, Jae Soo | - |
dc.contributor.author | Kim, Jae Yeol | - |
dc.contributor.author | Kim, Hye-Ryoun | - |
dc.contributor.author | Kim, Cheol Hyeon | - |
dc.contributor.author | Lee, Jae Cheol | - |
dc.date.available | 2019-05-30T03:42:31Z | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.issn | 2005-6184 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23424 | - |
dc.description.abstract | Background: The pathophysiologic mechanisms of radiation-induced lung injury should be elucidated to enhance the therapeutic efficacy of radiotherapy and to manage patients exposed to serious radiation by accident. It has been suggested that pro-inflammatory cytokines play an important role in radiation-induced effect on the lung. This study was aimed to investigate changes in pro-inflammatory cytokines such as TNF-α, MIP-2, IL-1β and HMGB1, a newly recognized inflammatory mediator. Methods: The chests of BALB/c mice were selectively irradiated with single fraction of 20 Gy and then sacrificed at indicated times. Pathologic changes in the lung were examined after H&E staining. The expression level of pro-inflammatory cytokines was evaluated by ELISA kits in lung homogenate and in serum. Results: Radiation induced inflammatory changes and mild fibrosis in lung. Biphasic increase of TNF-α and IL-1β was found in lung homogenate at 4 hours and at 3 weeks after radiation. The elevation in the second phase tended to be more intense. However, there was no similar change in serum. MIP-2 level was slightly increased in lung homogenate at 4 hours, but not at 3 weeks. HMGB1 was increased at 3 weeks in serum while there was no significant change in lung homogenate. Conclusion: Radiation induced a biphasic increase in TNF-α and IL-1β. The effective control of second phase cytokine elevation should contribute to preventing severe lung fibrosis caused by radiation. Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.publisher | 대한결핵및호흡기학회 | - |
dc.title | Biphasic increase of pro-inflammatory cytokines in mice lung after irradiation | - |
dc.title.alternative | Biphasic Increase of Pro-inflammatory Cytokines in Mice Lung after Irradiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.4046/trd.2009.67.1.14 | - |
dc.identifier.bibliographicCitation | Tuberculosis and Respiratory Diseases, v.67, no.1, pp 14 - 20 | - |
dc.identifier.kciid | ART001366969 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-69049084913 | - |
dc.citation.endPage | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 14 | - |
dc.citation.title | Tuberculosis and Respiratory Diseases | - |
dc.citation.volume | 67 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Lung injury | - |
dc.subject.keywordAuthor | Radiation | - |
dc.subject.keywordPlus | cytokine | - |
dc.subject.keywordPlus | human menopausal gonadotropin | - |
dc.subject.keywordPlus | interleukin 1beta | - |
dc.subject.keywordPlus | macrophage inflammatory protein 2 | - |
dc.subject.keywordPlus | tumor necrosis factor alpha | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | Bagg albino mouse | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytokine production | - |
dc.subject.keywordPlus | enzyme linked immunosorbent assay | - |
dc.subject.keywordPlus | homogenate | - |
dc.subject.keywordPlus | irradiation | - |
dc.subject.keywordPlus | lung fibrosis | - |
dc.subject.keywordPlus | lung injury | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pneumonia | - |
dc.subject.keywordPlus | protein blood level | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | radiation dose | - |
dc.subject.keywordPlus | staining | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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