Biphasic increase of pro-inflammatory cytokines in mice lung after irradiationBiphasic Increase of Pro-inflammatory Cytokines in Mice Lung after Irradiation
- Authors
- Choi, Yun Jung; Rho, Jin Kyung; Jang, Won Seok; Lee, Seon Joo; Lee, Seung Sook; Koh, Jae Soo; Kim, Jae Yeol; Kim, Hye-Ryoun; Kim, Cheol Hyeon; Lee, Jae Cheol
- Issue Date
- Jul-2009
- Publisher
- 대한결핵및호흡기학회
- Keywords
- Cytokines; Lung injury; Radiation
- Citation
- Tuberculosis and Respiratory Diseases, v.67, no.1, pp 14 - 20
- Pages
- 7
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 67
- Number
- 1
- Start Page
- 14
- End Page
- 20
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23424
- DOI
- 10.4046/trd.2009.67.1.14
- ISSN
- 1738-3536
2005-6184
- Abstract
- Background: The pathophysiologic mechanisms of radiation-induced lung injury should be elucidated to enhance the therapeutic efficacy of radiotherapy and to manage patients exposed to serious radiation by accident. It has been suggested that pro-inflammatory cytokines play an important role in radiation-induced effect on the lung. This study was aimed to investigate changes in pro-inflammatory cytokines such as TNF-α, MIP-2, IL-1β and HMGB1, a newly recognized inflammatory mediator. Methods: The chests of BALB/c mice were selectively irradiated with single fraction of 20 Gy and then sacrificed at indicated times. Pathologic changes in the lung were examined after H&E staining. The expression level of pro-inflammatory cytokines was evaluated by ELISA kits in lung homogenate and in serum. Results: Radiation induced inflammatory changes and mild fibrosis in lung. Biphasic increase of TNF-α and IL-1β was found in lung homogenate at 4 hours and at 3 weeks after radiation. The elevation in the second phase tended to be more intense. However, there was no similar change in serum. MIP-2 level was slightly increased in lung homogenate at 4 hours, but not at 3 weeks. HMGB1 was increased at 3 weeks in serum while there was no significant change in lung homogenate. Conclusion: Radiation induced a biphasic increase in TNF-α and IL-1β. The effective control of second phase cytokine elevation should contribute to preventing severe lung fibrosis caused by radiation. Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
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