Effects of eugenol on Na+ currents in rat dorsal root ganglion neurons
- Authors
- Cho, Jeong Seon; Kim, Tae Hoon; Lim, Jae-Min; Song, Jin-Ho
- Issue Date
- Dec-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Dorsal root ganglion; Eugenol; Na+ current; Tetrodotoxin-resistant; Tetrodotoxin-sensitive
- Citation
- BRAIN RESEARCH, v.1243, pp 53 - 62
- Pages
- 10
- Journal Title
- BRAIN RESEARCH
- Volume
- 1243
- Start Page
- 53
- End Page
- 62
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23510
- DOI
- 10.1016/j.brainres.2008.09.030
- ISSN
- 0006-8993
1872-6240
- Abstract
- Eugenol is an aromatic molecule found in several plants and widely used in dentistry for analgesic and antiseptic purposes. It inhibits pro-inflammatory mediators including nitric oxide synthase, cyclooxygenase and lipoxygenase. It also regulates ion channels involved in pain signaling, such as TRPV1 receptor, high-voltage-activated Ca2+ channels, NMDA receptor and GABA(A) receptor. The expression and functional properties of voltage-gated Na+ channels in primary sensory neurons are altered following inflammation or nerve injury. To elucidate an involvement of Na+ channels in-the eugenol-induced analgesia we investigated the effects of eugenol on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) Na+ currents in acutely dissociated rat dorsal root ganglion neurons. Eugenol inhibited TTX-S and TTX-R Na+ currents in a concentration-dependent manner. The K-d values were 308 PM and 543 mu M, respectively. Eugenol did not influence the activation voltage of either type of Na+ current. However, eugenol moved the steady-state inactivation curves of both Na+ currents to a hyperpolarizing direction and reduced the maximal Na+ current. Thus eugenol appears to inhibit Na+ currents through its interaction with both resting and inactivated Na+ channels. The recovery from inactivation of both Na+ currents was slowed by eugenol. The eugenol inhibition of Na+ currents was not dependent on the stimulus frequency. The inhibition of Na+ currents is considered as one of the mechanisms by which eugenol exerts analgesia. (C) 2008 Elsevier B.V. All rights reserved.
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