Characterization of Heterogeneous LSU rRNA Profiles in Streptomyces coelicolor Under Different Growth Stages and Conditions
- Authors
- Kim, Hyun-Lee; Song, Woo-Seok; Kim, Kyungsub; Lee, Kangseok
- Issue Date
- Dec-2008
- Publisher
- SPRINGER
- Citation
- CURRENT MICROBIOLOGY, v.57, no.6, pp 537 - 541
- Pages
- 5
- Journal Title
- CURRENT MICROBIOLOGY
- Volume
- 57
- Number
- 6
- Start Page
- 537
- End Page
- 541
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23540
- DOI
- 10.1007/s00284-008-9238-1
- ISSN
- 0343-8651
1432-0991
- Abstract
- The Streptomyces coelicolor genome harbors six copies of divergent large subunit (LSU) rRNA genes that constitute five kinds of LSU rRNA species in a cell. We report here that each heterogeneous LSU rRNA species is differentially expressed during morphological development. However, differential expression of rRNA species was not affected by depletion of a specific nutrient such as carbon, nitrogen, or phosphate from the culture medium. Analysis of the upstream region of the rRNA operons revealed that each operon contains a different composition of conserved rRNA gene promoters, indicating that each operon is independently regulated at the transcriptional level. These findings imply the existence of a regulatory mechanism that controls the independent expression of each LSU rRNA and a possible role of different species of LSU rRNA in posttranscriptional regulation of gene expression during the life cycle of this developmentally complex microorganism.
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