Granulocyte macrophage colony-stimulating factor may modulate the post-transcription pathway of interleukin-6 expression in prostate carcinoma cells
- Authors
- Kim, Tae-Hyoung; Oh, Seung-Young; Kim, Young-Sun; Lee, Mi-Kyung; Kim, Hwa-Su; Myung, Soon-Chul
- Issue Date
- Feb-2008
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- prostatic neoplasms; interleurkin-6; granulocyte-macrophage colony-stimulating factor
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.23, no.1, pp 94 - 97
- Pages
- 4
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 23
- Number
- 1
- Start Page
- 94
- End Page
- 97
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23854
- DOI
- 10.3346/jkms.2008.23.1.94
- ISSN
- 1011-8934
1598-6357
- Abstract
- Intedeukin-6 (IL-6) can stimulate a variety of tumors including prostatic carcinoma. Research has recently shown that IL-6 may act to stimulate the progression of prostatic cancer. To date, little research has been performed to better understand the nature of granulocyte macrophage colony-stimulating factor (GM-CSF) and the expression of IL-6. The aim of this study was to evaluate the effects of GM-CSF on the expression of IL-6 in prostate cancer-3 (PC-3) cells. The bone-derived PC-3 cell line was used in this study. Reverse transcription polymerase chain reaction (RT-PCR) and real-time PCR were performed to detect IL-6 mRNA expression. The IL-6 protein was measured by enzyme-linked immunosorbent assay (ELISA) after treatment with hGM-CSF, Our data indicated that IL-6 mRNA expression did not increase after treatment with hGM-CSF in comparison to the control group. However, the expression of IL-6 protein was increased compared to the control group. GM-CSF may modulate the post-transcription pathway of IL-6 expression in prostate carcinoma cells. Our data suggest that GM-CSF may have a role in IL-6-mediated development of prostate cancer.
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