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Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester
- Authors
- Bhandari, Krishna Hari; Lee, Dong Xun; Newa, Madhuri; Yoon, Sung Il; Kim, Jung Sun; Kim, Dae Duk; Kim, Jung-Ae; Yoo, Bong Kyo; Woo, Jong Soo; Lyoo, Won Seok; Lee, Jae Hwi; Choi, Han Gon; Yong, Chul Soon
- Issue Date
- Feb-2008
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- fatty esters; ketorolac stearate; skin permeation; skin accumulation; local topical agent
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.31, no.2, pp 242 - 249
- Pages
- 8
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 31
- Number
- 2
- Start Page
- 242
- End Page
- 249
- ISSN
- 0253-6269
- Abstract
- The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption.
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