Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D-1-like receptors in mice
- Authors
- Shin, Eun-Joo; Jeong, Ji Hoon; Kim, Hyun Ji; Jang, Choon-Gon; Yamada, Klyofumi; Nabeshima, Toshitaka; Kim, Hyoung-Chun
- Issue Date
- Dec-2007
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
- Keywords
- extremely low frequency magnetic field; locomotor activity; dopaminergic receptor
- Citation
- JOURNAL OF PHARMACOLOGICAL SCIENCES, v.105, no.4, pp 367 - 371
- Pages
- 5
- Journal Title
- JOURNAL OF PHARMACOLOGICAL SCIENCES
- Volume
- 105
- Number
- 4
- Start Page
- 367
- End Page
- 371
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23893
- DOI
- 10.1254/jphs.SC0070348
- ISSN
- 1347-8613
1347-8648
- Abstract
- We demonstrated that exposure to extremely low frequency magnetic fields (ELF-MF) enhanced dopamine levels in the rat striatum. To extend our understanding, we examined the role of dopaminergic receptors in ELF-MF-induced behavioral changes. Exposure to ELF-MF (2.4 mT, 1 h/day, for one or seven days) enhanced locomotor activity in a time-dependent manner. This hyperlocomotor activity paralleled an increase in c-Fos-like immunoreactivity (c-Fos-IR). Pretreatment with SCH23390, a dopaminergic D-1-like receptor antagonist, but not with sulpiride, a. dopaminergic D-2-like receptor antagonist, inhibited ELF-MF-induced increased locomotor activity and c-Fos-IR. Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D-1-like receptors.
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