Traceless liquid-phase synthesis of biphenyls and terphenyls using pentaerythritol as a tetrapodal soluble support
- Authors
- Kim, Chul-Bae; Cho, Chul-Hee; Kim, Chang Keun; Park, Kwangyong
- Issue Date
- Nov-2007
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF COMBINATORIAL CHEMISTRY, v.9, no.6, pp 1157 - 1163
- Pages
- 7
- Journal Title
- JOURNAL OF COMBINATORIAL CHEMISTRY
- Volume
- 9
- Number
- 6
- Start Page
- 1157
- End Page
- 1163
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23928
- DOI
- 10.1021/cc700112x
- ISSN
- 1520-4766
1520-4774
- Abstract
- Application of a novel sulfonate-based traceless multifunctional linker, system using pentaerythritol as a tetrapodal, soluble support was demonstrated using liquid-phase parallel and combinatorial preparation of biphenyl and terphenyl compounds. Nickel-catalyzed reactions of pentaerythritol tetrakis(arenesulfonate)s with arylmagnesium bromides generated the desired products in sufficient yields through reductive cleavage/cross-coupling of the C-S bond.,, Homogeneous pentaerythritol-supported reactions could be accomplished using less nucleophile with shorter reaction periods than could the corresponding heterogeneous polymer-supported reactions. This liquid-phase approach using a small polyfunctionalized support combines advantages of solution-phase and solid-phase syntheses by allowing high reactivity, high atom economy, simple isolation, and real-time monitoring of the reaction progress.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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