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Neuroprotective effect of scopoletin from Angelica dahurica on oxygen and glucose deprivation-exposed rat organotypic hippocampal slice culture
- Authors
- Son, Dongwook; Lee, Pyeongjae; Lee, Jongseok; Lee, Sanghyun; Choi, Sang Yoon; Lee, Jong-Won; Kim, Sun Yeou
- Issue Date
- Aug-2007
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- Angelica dahurica; scopoletin; oxygen-glucose deprivation; hippocampus slice culture; neuroprotection
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.16, no.4, pp 632 - 635
- Pages
- 4
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 16
- Number
- 4
- Start Page
- 632
- End Page
- 635
- ISSN
- 1226-7708
2092-6456
- Abstract
- This study examined the neuroprotective effect of scopoletin from Angelica dahurica against oxygen and glucose deprivation-induced neurotoxicity in a rat organotypic hippocampal slice culture. Scopoletin reduced the propidium iodide (PI) uptake, which is an indication of impaired cell membrane integrity. In addition, it inhibited the loss of NeuN, which represents the viability of neuronal cells. The results suggests that scopoletin from A. dahurica protects neuronal cells from the damage caused by oxygen and glucose deprivation.
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