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Immunohistochemical study on the distribution of canonical transient receptor potential channels in rat basal ganglia
- Authors
- Chung, Yoon Hee; Kim, Daejin; Moon, Nam Joo; Oh, Chang Seok; Lee, Eunju; Shin, Dong Hoon; Kim, Sung Su; Lee, Won Bok; Lee, Jun-Young; Cha, Choong Ik
- Issue Date
- Jul-2007
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- transient receptor potential (TRP) channels; TRPC; rat; basal ganglia; immunohistochemistry; Parkinson's disease (PD)
- Citation
- NEUROSCIENCE LETTERS, v.422, no.1, pp 18 - 23
- Pages
- 6
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 422
- Number
- 1
- Start Page
- 18
- End Page
- 23
- ISSN
- 0304-3940
1872-7972
- Abstract
- In the present study, we examined the localizations of canonical transient receptor potential channels (TRPCs) in rat basal ganglia. The dotlike staining pattern of TRPC5 was observed through the globus pallidus (GP) and caudate-putamen. TRPC7 had a strikingly high level of expression in the neuropil in the GP. In the subthalamic nucleus, strong staining for TRPC5 was observed in the cell bodies, while moderate to high immunoreactivies for TRPC 1, TRPC3, TRPC4 and TRPC7 were found in the cell bodies and surrounding neuropil. In the substantia nigra, immunoreactivities for TRPC3 and TRPC7 were prominent in the cell bodies and several processes in the pars compacta and pars reticulata. TRPC6 was expressed in the neuropil, not in the cell bodies. This study may provide useful data for the future investigations on the structural and functional proper-ties of TRPCs. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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