Preparation and magnetic resonance imaging effect of polyvinylpyrrolidone-coated iron oxide nanoparticles
- Authors
- Lee, Ha Young; Lim, Nak Hyun; Seo, Jin A.; Yuk, Soon Hong; Kwak, Byung Kook; Khang, Gilson; Lee, Hai Bang; Cho, Sun Hang
- Issue Date
- Oct-2006
- Publisher
- WILEY-LISS
- Keywords
- biomaterials availability; coating(s); in vivo; nanotechnology
- Citation
- JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v.79B, no.1, pp 142 - 150
- Pages
- 9
- Journal Title
- JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
- Volume
- 79B
- Number
- 1
- Start Page
- 142
- End Page
- 150
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24268
- DOI
- 10.1002/jbm.b.30524
- ISSN
- 1552-4973
1552-4981
- Abstract
- Polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles were prepared by the thermal decomposition of Fe(CO)(5) (iron pentacarbonyl) in one step. X-ray diffraction (XRD), transmission electron microscopy (TEM), electrophoretic light scattering (ELS), infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) together with the variation of the molar ratio of PVP/Fe(CO)(5), solvent, and molecular weight of PVP, were used to characterize the PVP-coated iron oxide nanoparticles. Fifty to hundred nanometer-sized iron oxide nanoclusters with a spherical shape were formed in dimethylformamide (DNIF), used as a solvent, and exhibited an enhanced stability in the aqueous media. Their magnetic properties were investigated by superconducting quantum interface device (SQUID). The in vitro cytotoxicity test revealed that the PVP-coated iron oxide nanoparticles exhibited excellent biocompatibility by MTT assay. Magnetic resonance imaging (MRI) effect was observed with the administration of PVP-coated iron oxide nanoparticles through the marginal vein of rabbit, resulting in improved detection of the liver lesions. (c) 2006 Wiley Periodicals, Inc.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24268)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.