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RraA rescues Escherichia coli cells over-producing RNase E from growth arrest by modulating the ribonucleolytic activity
- Authors
- Yeom, Ji-Hyun; Lee, Kangseok
- Issue Date
- Jul-2006
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- RraA; RNase E; degradosome; mRNA abundance; endoribonuclease
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.345, no.4, pp 1372 - 1376
- Pages
- 5
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 345
- Number
- 4
- Start Page
- 1372
- End Page
- 1376
- ISSN
- 0006-291X
1090-2104
- Abstract
- RraA is an evolutionary conserved protein inhibitor of RNase E, which catalyzes the initial step in the decay and processing of numerous RNAs in Escherichia coli and forms the core component of the degradosome, a large protein complex involved in RNA metabolism. Here, we report that co-expression of RraA reduces the ribonucleolytic activity in cells over-producing RNase E and consequently rescues these cells from growth arrest. These findings suggest that inability of cells over-producing RNase E to normally grow results from increased cellular ribonucleolytic activity and RraA is able to effectively modulate the catalytic activity of RNase E in vivo. (c) 2006 Elsevier Inc. All rights reserved.
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