Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677,1298 gene polymorphism in Korean schizophrenic patients
- Authors
- Lee, YS; Han, DH; Jeon, CM; Lyoo, IK; Na, C; Chae, SL; Cho, SC
- Issue Date
- May-2006
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- folate; homocysteine; methylenetetrahydrofolate reductase; polymorphism; schizophrenia
- Citation
- NEUROREPORT, v.17, no.7, pp 743 - 746
- Pages
- 4
- Journal Title
- NEUROREPORT
- Volume
- 17
- Number
- 7
- Start Page
- 743
- End Page
- 746
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24352
- DOI
- 10.1097/01.wnr.0000215777.99473.52
- ISSN
- 0959-4965
1473-558X
- Abstract
- High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level, of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.