Electrically stimulated relaxation is not mediated by GABA in cat lower esophageal sphincter muscle
DC Field | Value | Language |
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dc.contributor.author | Park, SY | - |
dc.contributor.author | Shin, CY | - |
dc.contributor.author | Song, HJ | - |
dc.contributor.author | Min, YS | - |
dc.contributor.author | La, HO | - |
dc.contributor.author | Lee, JW | - |
dc.contributor.author | Kim, DY | - |
dc.contributor.author | Je, HD | - |
dc.contributor.author | Sohn, UD | - |
dc.date.available | 2019-05-30T07:32:33Z | - |
dc.date.issued | 2006-05 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24365 | - |
dc.description.abstract | This study examined the effect of Gamma-Amino butyric acid (GABA) and selective GABA receptor related drugs on the electrically stimulated relaxation in the lower esophageal sphincter muscle (LES) of a cat. Tetrodotoxin (10(-6) M) suppressed the electrically stimulated (0.5-5 Hz) relaxation of the LES. However, guanethidine (10(-6) M) and atropine (10(-6) M) had no effect indicating that the relaxations were neurally mediated via the nonadrenergic and noncholinergic (NANC) pathways. NG-nitro-L-arginine methyl ester (10(-4) M, L-NAME) also inhibited the relaxant response but did not completely abolish the electrically stimulated relaxation with 60 % inhibition, which suggests the involvement of nitric oxide as an inhibitory transmitter. This study examined the role of GABA, an inhibitory neurotransmitter, on neurally mediated LES relaxation. GABA (10(-3)-10(-5) M, non selective receptor agonist), muscimol (10(-3)-10(-5) M, GABA-A agonist), and baclofen (10(-3)-10(-3) M, GABA-B agonist) had no significant effect on the electrically stimulated relaxation. Moreover, bicuculline (10(-5) M, GABA-A antagonist) and phaclofen (10(-5) M, GABA-B antagonist) had no inhibitory effect on the electrically stimulated relaxation. This suggests that GABA and the GABA receptor are not involved in the electrically stimulated NANC relaxation in the cat LES. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.title | Electrically stimulated relaxation is not mediated by GABA in cat lower esophageal sphincter muscle | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/BF02968590 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.29, no.5, pp 400 - 404 | - |
dc.identifier.kciid | ART001017438 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000237932800009 | - |
dc.identifier.scopusid | 2-s2.0-33744937574 | - |
dc.citation.endPage | 404 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 400 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | lower esophageal sphincter | - |
dc.subject.keywordAuthor | GABA | - |
dc.subject.keywordAuthor | electrical field stimulation | - |
dc.subject.keywordAuthor | nonadrenergic noncholinergic neuron | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | relaxation | - |
dc.subject.keywordPlus | VASOACTIVE INTESTINAL POLYPEPTIDE | - |
dc.subject.keywordPlus | INHIBITORY MOTOR-NEURONS | - |
dc.subject.keywordPlus | GUINEA-PIG ILEUM | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | NEUROTRANSMITTER | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | VIP | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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