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High-performance liquid chromatographic-tandem mass spectrometric determination of Itraconazole in human plasma for bioavailability and bioequivalence studies
- Issue Date
- Feb-2006
- Publisher
- KOREAN CHEMICAL SOC
- Keywords
- high-performance liquid chromatography-tandem mass spectrometry; itraconazole; bioequivalence
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.27, no.2, pp 291 - 294
- Pages
- 4
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 27
- Number
- 2
- Start Page
- 291
- End Page
- 294
- ISSN
- 0253-2964
1229-5949
- Abstract
- A highly sensitive high-performance liquid chromatographic-tandem mass spectrometric method (HPLC-MSMS) has been developed to quantify itraconazole in human plasma for the purpose of pharmacokinetic studies. Sample preparation was carried out by liquid-liquid extraction using loratadine as an internal standard. Chromatographic separation used a YMC C-18 column, giving an extremely fast total run time of 3 min. The method was validated and used for the bioequivalence Study of itraconazole tablets in healthy male volunteers (n = 31). The lower limit of detection proved to be 0.2 mg/mL for itraconazole.
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