Intrinsic adhesion properties of poly(vinyl pyrrolidone) to pharmaceutical materials: Humidity effect
DC Field | Value | Language |
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dc.contributor.author | Lee, Jonghwi | - |
dc.date.available | 2019-05-30T07:35:32Z | - |
dc.date.issued | 2005-11 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.issn | 1616-5195 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24481 | - |
dc.description.abstract | Poly(vinyl pyrrolidone) (PVP) is widely used for bioengineering and pharmaceutical applications, and its adhesion characteristics are critical. When used as a binder in pharmaceutical granulation, it covers the resultant-granules and governs their surface properties. The intrinsic adhesion forces of PVP toward common hydrophobic (magnesium stearate) and hydrophilic (lactose) pharmaceutical materials have been studied as a function of relative humidity (RH). The effect of RH on adhesion force was more significant for the PVP/hydrophilic material than the PVP/hydrophobic material. Adhesion was lowest between 20 and 40% RH, and it increased at RH above 40% and below 20%. This is likely to be due to the development of capillary and triboelectrification forces, respectively. In a nano-indentation experiment using a silicon tip at room temperature, the PVP surface underwent a glass transition at 70% RH. This result suggests that surface softening contributes to the increased PVP adhesion at RH above 70%. To adjust the adhesion properties of PVP, humidity control should be an essential part of research and development. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Intrinsic adhesion properties of poly(vinyl pyrrolidone) to pharmaceutical materials: Humidity effect | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/mabi.200500146 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.5, no.11, pp 1085 - 1093 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000233524100005 | - |
dc.identifier.scopusid | 2-s2.0-28444461882 | - |
dc.citation.endPage | 1093 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1085 | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 5 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | adhesion | - |
dc.subject.keywordAuthor | atomic force microscopy (AFM) | - |
dc.subject.keywordAuthor | drug delivery systems | - |
dc.subject.keywordAuthor | hydrophilic polymer | - |
dc.subject.keywordAuthor | poly(vinyl pyrrolidone) (PVP) | - |
dc.subject.keywordAuthor | surfaces | - |
dc.subject.keywordPlus | ATOMIC-FORCE MICROSCOPY | - |
dc.subject.keywordPlus | GLASS-TRANSITION TEMPERATURE | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | POWDERS | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | CANTILEVERS | - |
dc.subject.keywordPlus | FRICTION | - |
dc.subject.keywordPlus | INHALER | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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