Intrinsic adhesion properties of poly(vinyl pyrrolidone) to pharmaceutical materials: Humidity effect
- Authors
- Lee, Jonghwi
- Issue Date
- Nov-2005
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- adhesion; atomic force microscopy (AFM); drug delivery systems; hydrophilic polymer; poly(vinyl pyrrolidone) (PVP); surfaces
- Citation
- MACROMOLECULAR BIOSCIENCE, v.5, no.11, pp 1085 - 1093
- Pages
- 9
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 5
- Number
- 11
- Start Page
- 1085
- End Page
- 1093
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24481
- DOI
- 10.1002/mabi.200500146
- ISSN
- 1616-5187
1616-5195
- Abstract
- Poly(vinyl pyrrolidone) (PVP) is widely used for bioengineering and pharmaceutical applications, and its adhesion characteristics are critical. When used as a binder in pharmaceutical granulation, it covers the resultant-granules and governs their surface properties. The intrinsic adhesion forces of PVP toward common hydrophobic (magnesium stearate) and hydrophilic (lactose) pharmaceutical materials have been studied as a function of relative humidity (RH). The effect of RH on adhesion force was more significant for the PVP/hydrophilic material than the PVP/hydrophobic material. Adhesion was lowest between 20 and 40% RH, and it increased at RH above 40% and below 20%. This is likely to be due to the development of capillary and triboelectrification forces, respectively. In a nano-indentation experiment using a silicon tip at room temperature, the PVP surface underwent a glass transition at 70% RH. This result suggests that surface softening contributes to the increased PVP adhesion at RH above 70%. To adjust the adhesion properties of PVP, humidity control should be an essential part of research and development.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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