Bioequivalence trials with the incomplete 3X3 crossover design
- Authors
- Lim, N.K.; Park, Sang-Gue; Stanek, E
- Issue Date
- Oct-2005
- Publisher
- AKADEMIE VERLAG GMBH
- Keywords
- average bioequivalence; 3 X 3 crossover design; missing data; least square estimator
- Citation
- BIOMETRICAL JOURNAL, v.47, no.5, pp 635 - 643
- Pages
- 9
- Journal Title
- BIOMETRICAL JOURNAL
- Volume
- 47
- Number
- 5
- Start Page
- 635
- End Page
- 643
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24517
- DOI
- 10.1002/bimj.200410144
- ISSN
- 0323-3847
1521-4036
- Abstract
- In bioequivalence trials, one often considers two or more generic products with the original one. The 3 x 3 crossover design can be adopted to evaluate the two generic candidates with a brand name drug, rather than conducting two separate 2 x 2 crossover trials. Dropouts, however, are more likely to occur due to various administrative reasons when we consider a higher order crossover design. A modified method, which was originally given by Chow and Shao (1997), is extended to compare two generic products with a reference in the incomplete 3 x 3 crossover design. A simulation study and discussion are also presented.
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Collections - College of Business & Economics > Department of Applied Statistics > 1. Journal Articles
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