Neuroprotective effect of ginseng total saponins in experimental traumatic brain injury
- Authors
- Ji, Yong Cheol; Kim, Young Baeg; Park, Seung Won; Hwang, Sung Nam; Min, Byung Kook; Hong, Hyun Jong; Kwon, Jeong Taik; Suk, Jong Sik
- Issue Date
- Apr-2005
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- brain injuries; panax; saponins; neuroprotective agents; hippocampus
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.20, no.2, pp 291 - 296
- Pages
- 6
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 20
- Number
- 2
- Start Page
- 291
- End Page
- 296
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24636
- DOI
- 10.3346/jkms.2005.20.2.291
- ISSN
- 1011-8934
1598-6357
- Abstract
- In the present study, we investigated whether ginseng total saponins (GTSs) protect hippocampal neurons after experimental traumatic brain injury (TBI) in rats. A moderate-grade TBI was made with the aid of a controlled cortical impact (CCI) device set at a velocity of 3.0 m/sec, a deformation of 3.0 mm, and a compression time of 0.2 sec at the right parietal area for adult male Sprague-Dawley rats. Shamoperated rats that underwent craniectomy without impact served as controls. GTSs (100 and 200 mg/kg) or saline was injected intraperitoneally into the rats immediately post-injury. Twenty-four hours after the injury, the rats underwent neurological evaluation. Contusion volume and the number of hippocampal neurons were calculated with apoptosis evaluated by TUNEL staining. 24 hr post-injury, saline-injected rats showed a significant loss of neuronal cells in the CA2 region of the right hippocampus (53.4%, p < 0.05) and CA3 (34.6%, p < 0.05) compared with contralateral hippocampal region, a significant increase in contusion volume (34 +/- 8 mu L), and significant increase in neurologic deficits compared with the GTSs groups. Treating rats with GTSs seemed to protect the CCI-induced neuronal loss in the hippocampus, decrease cortical contusion volume, and improve neurological deficits.
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