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Down-regulated reactive oxygen species by HSP90 in 3HK-induced SKN-SH cell death
- Authors
- Lee, Myoung-Woo; Lee, Hyun Jung; Bach, Jae-Hyung; Park, Soon Cheol; Park, Jin Sik; Lee, Kwang-Gill; Yeo, , Joo-Hong; Lee, Won Bok; Lee, Sang Hyung; Kim, Sung Su
- Issue Date
- Jan-2005
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- 3-hydroxykynurenine (3HK); Apoptosis; Caspase; Heat shock protein 90 (HSP90); Reactive oxygen species (ROS)
- Citation
- JOURNAL OF THERMAL BIOLOGY, v.30, no.1, pp 43 - 49
- Pages
- 7
- Journal Title
- JOURNAL OF THERMAL BIOLOGY
- Volume
- 30
- Number
- 1
- Start Page
- 43
- End Page
- 49
- ISSN
- 0306-4565
- Abstract
- In this present study, we show that 3HK induced reactive oxygen species (ROS) accumulation and after caspase activation lead to apoptotic cell death. Pretreatment with N-acetylcysteine (NAC). an effective antioxidant significantly attenuated 3HK-induced apoptosis by way of a reduction of ROS accumulation and caspase activity. SKN-SN cells were protected from 3HK-induced cytotoxicity by heat shock protein (HSP). HSP effectively attenuated 3HK-mediated ROS accumulation and apoptosis. In addition, the protective effect of HSP90 was abolished by pretreatment with HSP90 anti-sense oligonucleotides, but not when pretreated with anti-senses for other HSPs. These results suggest that HSP90 protects SKN-SH cells from 3HK-induced cytotoxicity by reducing ROS levels and caspase activity. (C) 2004 Elsevier Ltd. All rights reserved.
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