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Average bioequivalence for two-sequence two-period crossover design with incomplete data
- Authors
- Lee, J.-Y.; Kim, B.-C.; Park, Sang-Gue
- Issue Date
- Oct-2005
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- average bioequivalence; incomplete crossover design; maximum likelihood estimation; missing at random
- Citation
- JOURNAL OF BIOPHARMACEUTICAL STATISTICS, v.15, no.5, pp 857 - 867
- Pages
- 11
- Journal Title
- JOURNAL OF BIOPHARMACEUTICAL STATISTICS
- Volume
- 15
- Number
- 5
- Start Page
- 857
- End Page
- 867
- ISSN
- 1054-3406
1520-5711
- Abstract
- A statistical procedure for analyzing a two-sequence two-period crossover design in bioequivalence trials is discussed when some observations at the second period are missing. The maximum likelihood estimators of the parameters in the average bioequivalence model are obtained under missing at random and a modified two one-sided test is proposed. The performances of the discussed test are compared using Monte Carlo simulations.
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