Distribution of human group A rotavirus VP7 and VP4 types circulating in Seoul, Korea between 1998 and 2000
- Authors
- Song, Mi-Ok; Kim, Ki-Jung; Chung, Sang-In; Lim, Inseok; Kang, Shien-young; An, Chang-Nam; Kim, Wonyong
- Issue Date
- Jun-2003
- Publisher
- WILEY
- Keywords
- rotavirus; Korea; G-type; P-type; ELISA; RT-PCR
- Citation
- JOURNAL OF MEDICAL VIROLOGY, v.70, no.2, pp 324 - 328
- Pages
- 5
- Journal Title
- JOURNAL OF MEDICAL VIROLOGY
- Volume
- 70
- Number
- 2
- Start Page
- 324
- End Page
- 328
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24985
- DOI
- 10.1002/jmv.10398
- ISSN
- 0146-6615
1096-9071
- Abstract
- Three hundred forty-eight fecal specimens collected from young children with acute diarrhea in Seoul, Korea between January 1998 and February 2000 were examined for G and P types. Of these, 205 samples (59%) were confirmed as group A rotavirus by ELISA for the detection of VP6 antigen. Confirmed rotavirus isolates were characterized using G serotyping ELISA and RTPCR methodologies for G and P genotyping of the outer capsid proteins VP7 and VP4, respectively. Serotyping of the outer capsid protein, VP7, revealed G4 as the dominant circulating serotype (41%) followed by G1 (28%) and quite a high incidence of mixed infection (14%). Geno-typing of the VP4 protein was carried out on 55 of the rotavirus isolates with the dominant type being P[8] (46%). Of interest were a number of unusual G and P type combinations detected in Korea for the first time, especially the P[4] genotype associated with non-G2 serotypes. There were also a number of P[6] isolates identified including one G2P[6] isolate.
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