Detailed Information
Cited 22 time in 
Cited 31 time in 
Cited 31 time in
Metadata Downloads
Inhibition of HIV-1 reverse transcriptase and HIV-1 integrase and antiviral activity of Korean seaweed extracts
- Authors
- Ahn, Mi-Jeong; Yoon, Kee-Dong; Kim, Chul Young; Min, So-Young; Kim, Yong-ung; Kim, Hyun Jin; Kim, Jeong Ha; Shin, Cha-Gyun; Lee, Chong-Kyo; Kim, Tae Gyun; Kim, SH; Huh, Hoon; Kim, Jinwoong
- Issue Date
- Oct-2002
- Publisher
- KLUWER ACADEMIC PUBL
- Keywords
- antiviral activity; HIV-1 integrase; HIV-1 reverse transcriptase; macroalgae; seaweed extracts
- Citation
- JOURNAL OF APPLIED PHYCOLOGY, v.14, no.5, pp 325 - 329
- Pages
- 5
- Journal Title
- JOURNAL OF APPLIED PHYCOLOGY
- Volume
- 14
- Number
- 5
- Start Page
- 325
- End Page
- 329
- ISSN
- 0921-8971
1573-5176
- Abstract
- Forty-seven species of marine macroalgae from the coast of Korea have been screened for the presence of inhibitory compounds against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and HIV-1 integrase (IN). One of 4 Chlorophyta, 8 of 17 Phaeophyta and 6 of 26 Rhodophyta showed inhibitory activity against HIV-1 reverse transcriptase. Five species (Ecklonia cava, Ishige okamurae, Sargassum confusum, Sargassum hemiphyllum, Sargassum ringgoldianum) belonging to Phaeophyta showed to inhibit the 3'-processing activity of HIV-1 integrase. In cell-based assays, the methanol extracts of Bossiella sp. and Chondria crassicaulis inhibited cytopathogenecity of HIV-1 at a concentration below that cytotoxic for MT4 cells.
- Files in This Item
- There are no files associated with this item.
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.