Induction of cytochrome P450 1A and 213 by (alpha- and beta-ionone in Sprague Dawley rats
- Authors
- Jeong, HG; Chun, YJ; Yun, CH; Moon, CK; Lee, HS; Han, SS; Lee, ES; Jeong, TC
- Issue Date
- Apr-2002
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Keywords
- induction; cytochrome P4502B; ionones
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.25, no.2, pp 197 - 201
- Pages
- 5
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 25
- Number
- 2
- Start Page
- 197
- End Page
- 201
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25132
- DOI
- 10.1007/BF02976563
- ISSN
- 0253-6269
- Abstract
- beta-lonone has been reported to induce the cytochrome P450 (P450) 2131 in rats. In this study, the effects of beta-ionone and an isomer, alpha-ionone, on liver P450 1A and 2B expression in Sprague Dawley rats were investigated. Subcutaneous administration of alpha- and beta-ionone 72 and 48 hr prior to sacrificing the animals induced the liver microsomal P450 1 A and 2B proteins. P450 2B1 induction was associated with the accumulation of its corresponding mRNA. Induction by beta-ionone was much higher than that by alpha-ionone in both the mRNA and protein levels. When the route of administration was compared, P450 2B was induced more strongly after oral administration compared to that after subcutaneous injection. A single oral dose of 100, 300 and 600 mg/kg of alpha- and beta-ionone for 24 h induced P450 2B1-selective pentoxyresorufln O-depentylase activity comparably in a dose-dependent manner. In addition, alpha- and beta-ionone induced the P450 1A and 2B proteins. These results suggest that alpha- and beta-ionone might be potent P450 2B1 inducers in rats, and that both ionones may be useful for examining the role of metabolic activation in chemical-induced toxicity where metabolic activation is required.
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