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Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides
- Issue Date
- Aug-2000
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.10, no.16, pp 1879 - 1882
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 10
- Number
- 16
- Start Page
- 1879
- End Page
- 1882
- ISSN
- 0960-894X
1464-3405
- Abstract
- Caffeoylglucosides, which have a glucose ring as a central linker, were synthesized from methyl D-glucosides, and their anti-HIV-1 activities were tested. Among them, four dicaffeoylglucosides (IC50 = 29.1-35.1 mu M), 6a, 6b, 9b and 10b, showed HIV-1 integrase inhibitory activity as potent as L-chicoric acid. (C) 2000 Elsevier Science Ltd. All rights reserved.
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