Influence of menopause on high density lipoprotein-cholesterol and lipids
- Authors
- Kim, Chee Jeong; Kim, Tae Ho; Ryu, Wang Seong; Ryoo, Un Ho
- Issue Date
- Aug-2000
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- hormones; female; lipoproteins; lipids; menopause
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.15, no.4, pp 380 - 386
- Pages
- 7
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 15
- Number
- 4
- Start Page
- 380
- End Page
- 386
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/25300
- DOI
- 10.3346/jkms.2000.15.4.380
- ISSN
- 1011-8934
1598-6357
- Abstract
- It has been generally accepted that high density lipoprotein cholesterol (HDL-C) level decreases with menopause in women. However, recent reports show different results. There is very little data concerning perimenopausal women. To verify these findings, lipids and lipoprotein(a) [Lp(a)] levels were compared among pre-, peri- and postmenopausal women of similar mean ages. Postmenopausal women had higher HDL-C levels than premenopausal women (p<0.001) and there was no difference between peri- and postmenopausal women. LDL-C level in perimenopausal women was lower than in postmenopausal women (p<0.001) and higher than in premenopausal women with borderline significance (p=.051). Total cholesterol levels showed stepwise elevation from premenopause to postmenopause. Perimenopausal women had lower Lp(a) levels than postmenopausal women (p<0.0005) and similar levels to premenopausal women. Lp(a) levels between 0.1 to 10.0 mg/dL were the most prevalent in pre- and perimenopausal women, and those between 10.1 to 20.0 mg/dL in postmenopausal women. In conclusion, menopause itself is associated with the elevation of HDL-C level, and the postmenopausal increase of coronary artery disease is not related to postmenopausal change of HDL-C level. Perimenopausal status, although transient, may favor Lp(a) and lipid profiles for delaying atherosclerosis.
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