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Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica
- Issue Date
- Apr-2000
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- Alnus hirsuta var. sibirica; cyclooxygenase-2 inhibitor; diarylheptanoid
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.23, no.4, pp 517 - 518
- Pages
- 2
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 23
- Number
- 4
- Start Page
- 517
- End Page
- 518
- ISSN
- 0918-6158
1347-5215
- Abstract
- Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranoside and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydrosxphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.
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